Robinul Forte

Generic Name: glycopyrrolate (Oral route)

glye-koe-PIR-oh-late

Commonly used brand name(s)

In the U.S.

• Cuvposa


• Robinul


• Robinul Forte

Available Dosage Forms:

• Tablet


• Solution

Therapeutic Class: Gastrointestinal Agent

Pharmacologic Class: Antimuscarinic

Uses For Robinul Forte

Glycopyrrolate is used to treat peptic ulcers in adults. It is also used to treat chronic, severe drooling caused by certain neurologic disorders (e.g., cerebral palsy) in children 3 to 16 years of age. This medicine is an anticholinergic.

Glycopyrrolate may also be used for other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Before Using Robinul Forte

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of glycopyrrolate in children 3 to 16 years of age. However, safety and efficacy have not been established in children younger than 3 years of age.

Geriatric

No information is available on whether the risk of glycopyrrolate-induced adverse effects are increased in the elderly; however, it should be used with caution because elderly patients are more likely to have age related liver disease, kidney disease, heart disease, or prostate problems. This may require a dosage adjustment or careful monitoring in elderly patients receiving glycopyrrolate.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Colostomy (bowel surgical procedure) or


• Congestive heart failure or


• Heart disease or


• Heart rhythm problems or


• Hiatal hernia with gastroesophageal reflux disease (GERD) or


• Hypertension (high blood pressure) or


• Hyperthyroidism (overactive thyroid) or


• Ileostomy (bowel surgical procedure) or


• Liver disease or


• Nerve problems (e.g., neuropathy) or


• Prostatic hypertrophy (enlarged prostate) or


• Ulcerative colitis—Use with caution. May make these conditions worse.

• Glaucoma or


• Myasthenia gravis (severe muscle weakness) or


• Obstructive uropathy (urinary blockage due to enlarged prostate or other condition) or


• Paralytic ileus (bowel blockage) or


• Stomach or intestinal problems (e.g., ulcerative colitis, toxic megacolon, bowel obstruction), severe or


• Trouble urinating—Should not be used in patients with these conditions.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of glycopyrrolate

This section provides information on the proper use of a number of products that contain glycopyrrolate. It may not be specific to Robinul Forte. Please read with care.

Your doctor will tell you how much of this medicine to use and how often. The dose may need to be changed several times in order to find out what works best for you or your child. Do not use more medicine or use it more often than your doctor tells you to.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

You should take this medicine at least one hour before or two hours after meals.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (solution):
  
  • For severe drooling:
    
    • Children 3 to 16 years of age—Dose is based on body weight and must be determined by your child's doctor. The dose is 0.02 milligram (mg) per kilogram (kg) of body weight three times a day. Your child's doctor may increase your child's dose as needed. However, the dose is usually not more than 1.5 to 3 mg per dose.
    
    
    • Children younger than 3 years of age—Use and dose must be determined by your child's doctor.
    
    
  
  


• For oral dosage form (tablet):
  
  • For peptic ulcers:
    
    • Adults and children 12 years of age and older—The initial dose is 1 mg three times daily. Your doctor will adjust the dose as needed. However, the dose is usually not more than 8 mg per day.
    
    
    • Children younger than 12 years of age—Use is not recommended.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Robinul Forte

It is very important that your doctor or your child's doctor check your progress at regular visits. This will allow your doctor to make sure that this medicine is working properly and to check for unwanted effects.

You should not take potassium chloride tablets or other potassium supplements (in tablet or capsule forms) while is using this medicine. Using these medicines together may cause delayed movement of the potassium supplement through the esophagus and stomach.

This medicine may cause constipation or diarrhea. Constipation or diarrhea can be an early symptom of a serious bowel problem. Stop using this medicine and check with your doctor if you or your child has constipation, diarrhea, abdominal or stomach distention (swelling), pain, nausea, or vomiting.

Stop using this medicine and check with your doctor right away if your child is unable to urinate, has dry diapers or undergarments, or has the following symptoms while using this medicine: crying, irritability, decrease in the frequency of urine, or difficult or painful urination.

If you or your child develops a skin rash, hives, or any allergic reaction to this medicine, stop taking the medicine and check with your doctor as soon as possible.

This medicine may make you or your child sweat less, causing your body temperature to increase. Use extra care to avoid becoming overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heat stroke.

This medicine may make you or your child drowsy or cause blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Robinul Forte Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• chills


• constipation


• cough


• decrease in the frequency of urination


• decrease in urine volume


• difficulty in passing urine (dribbling)


• difficulty with breathing


• ear congestion


• feeling of warmth


• fever


• headache


• loss of voice


• nasal congestion


• painful urination


• redness of the face, neck, arms, and occasionally, upper chest


• runny nose


• sneezing


• sore throat


• unusual tiredness or weakness

Less common

• Abdominal or stomach discomfort or pain


• abdominal or stomach distension


• chest pain


• confusion


• convulsions


• dizziness


• dry heaves


• dry mouth


• fainting


• increase in heart rate


• lightheadedness


• pain or tenderness around the eyes and cheekbones


• rapid breathing


• shortness of breath or troubled breathing


• stuffy nose


• sunken eyes


• thirst


• tightness in the chest


• vomiting


• wheezing


• wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• low blood pressure


• muscle weakness


• trouble breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Altered mood


• anxiety


• attack, assault, or force


• bloated


• change in taste


• chapped lips


• crying


• dry skin


• dry tongue


• excess air or gas in the stomach or intestines


• full feeling


• hyperventilation


• irregular heartbeats


• irritability


• loss of taste


• moaning


• nervousness


• pain


• paleness of the skin


• passing gas


• rash


• restlessness


• shaking


• trouble with sleeping


• uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Robinul Forte side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Robinul Forte resources

• Robinul Forte Side Effects (in more detail)
• Robinul Forte Use in Pregnancy & Breastfeeding
• Drug Images
• Robinul Forte Drug Interactions
• Robinul Forte Support Group
• 0 Reviews for Robinul Forte - Add your own review/rating

• Robinul Forte MedFacts Consumer Leaflet (Wolters Kluwer)


• Glycopyrrolate Professional Patient Advice (Wolters Kluwer)


• Glycopyrrolate Monograph (AHFS DI)


• Glycopyrrolate MedFacts Consumer Leaflet (Wolters Kluwer)


• Cuvposa Prescribing Information (FDA)


• Cuvposa Consumer Overview


• Cuvposa Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Robinul Prescribing Information (FDA)

Compare Robinul Forte with other medications

• Anesthesia
• Peptic Ulcer

Dylix

Generic Name: dyphylline (dye FI lin)

Brand Names: Dilor, Dylix, Lufyllin, Neothylline

What is Dylix (dyphylline)?

Dyphylline is a bronchodilator. Dyphylline works in several ways: It relaxes muscles in your lungs and chest to allow more air in, it decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and it increases the contractions of your diaphragm to draw more air into the lungs.

Dyphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.

Dyphylline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Dylix (dyphylline)?

Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, an increased heart rate, or a headache. These could be signs of too much dyphylline in your blood.

Do not start or stop smoking without your doctor's knowledge. Smoking may affect your dosage.

Do not take more of this medicine than is prescribed without consulting your doctor. Seek medical attention if you are having increasing difficulty breathing.

Who should not take Dylix (dyphylline)?

Before taking this medication, tell your doctor if you have

• 
  

  a stomach ulcer;

  
  


• 
  

  seizures;

  
  


• 
  

  high blood pressure, a heart condition, or any type of heart disease;

  
  


• 
  

  fluid in your lungs;

  
  


• 
  

  a thyroid condition;

  
  


• 
  

  liver disease; or

  
  


• 
  

  kidney disease.

  
  

You may not be able to take dyphylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Dyphylline is in the FDA pregnancy category C. This means that it is not known whether dyphylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Dyphylline passes into breast milk and could affect a nursing baby. Do not take dyphylline without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from dyphylline. You may require a lower dose of this medication.

How should I take Dylix (dyphylline)?

Take dyphylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. You can take dyphylline with food to lessen stomach upset.

Take your doses at the same time every day to keep a constant level of dyphylline in your blood.

Shake the liquid forms of this medication well before use. To ensure that you get a correct dose, measure the liquid with a dose-measuring cup or spoon, not a regular tablespoon. If a spoon or cup is not provided with the medication and you do not have one, ask your pharmacist where you can get one.

Do not switch to another brand or a generic form of dyphylline without the approval of your doctor.

Store dyphylline at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a dyphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

What should I avoid while taking Dylix (dyphylline)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dyphylline may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Do not start or stop smoking without the approval of your doctor. Smoking changes the way your body uses dyphylline, and you may need a dose adjustment.

Avoid changing your dose or changing the time of your daily doses.

Do not change the brand, generic form, or formulation (tablet, capsule, liquid) of dyphylline that you are taking without the approval of your doctor. Different brands or formulations may require different dosages.

Avoid eating excessive amounts of grilled or char-broiled foods. Doing so may also change the dose of dyphylline that you need.

Avoid caffeinated beverages such as coffee, tea, and cola. Dyphylline is related chemically to caffeine, and you may experience some side effects if you consume too much caffeine.

Dylix (dyphylline) side effects

If you experience any of the following serious side effects, stop taking dyphylline and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  seizures;

  
  


• 
  

  increased or irregular heartbeats; or

  
  


• 
  

  severe nausea or vomiting.

  
  

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take dyphylline and talk to your doctor if you experience

• 
  

  slight nausea, decreased appetite, or weight loss;

  
  


• 
  

  restlessness, tremor, or insomnia; or

  
  


• 
  

  headache, lightheadedness, or dizziness.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dylix (dyphylline)?

Dyphylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal remedies, vitamins, and other nonprescription items.

The following drugs may increase the levels of dyphylline in your blood, leading to dangerous side effects:

• 
  

  alcohol;

  
  


• 
  

  cimetidine (Tagamet, Tagamet HB);

  
  


• 
  

  fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin);

  
  


• 
  

  clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, others);

  
  


• 
  

  disulfiram (Antabuse);

  
  


• 
  

  estrogens (Ogen, Premarin, and many other types);

  
  


• 
  

  fluvoxamine (Luvox);

  
  


• 
  

  methotrexate (Folex, Rheumatrex);

  
  


• 
  

  mexiletine (Mexitil) and propafenone (Rythmol);

  
  


• 
  

  propranolol (Inderal);

  
  


• 
  

  tacrine (Cognex);

  
  


• 
  

  ticlopidine (Ticlid); and

  
  


• 
  

  verapamil (Verelan, Calan, Isoptin).

  
  

The following drugs may decrease dyphylline levels in your blood, leading to poor asthma control:

• 
  

  aminoglutethimide (Cytadren),

  
  


• 
  

  carbamazepine (Tegretol),

  
  


• 
  

  isoproterenol (Isuprel),

  
  


• 
  

  moricizine (Ethmozine),

  
  


• 
  

  phenobarbital (Luminal, Solfoton),

  
  


• 
  

  phenytoin (Dilantin),

  
  


• 
  

  rifampin (Rifadin), and

  
  


• 
  

  sucralfate (Carafate).

  
  

Drugs other than those listed here may also interact with dyphylline or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Dylix resources

• Dylix Side Effects (in more detail)
• Dylix Use in Pregnancy & Breastfeeding
• Dylix Drug Interactions
• Dylix Support Group
• 0 Reviews for Dylix - Add your own review/rating

• Dylix Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Dylix Advanced Consumer (Micromedex) - Includes Dosage Information


• Dyphylline Professional Patient Advice (Wolters Kluwer)


• Dilor MedFacts Consumer Leaflet (Wolters Kluwer)


• Lufyllin Prescribing Information (FDA)

Compare Dylix with other medications

• Asthma
• Bronchitis
• COPD

Where can I get more information?

• Your pharmacist has additional information about dyphylline written for health professionals that you may read.

See also: Dylix side effects (in more detail)